BIO402Advanced Human Physiology & PathophysiologyLIVE

Renal Countercurrent Multiplication & Tubular Acid-Base Homeostasis • Instructor: Prof. Marcus Vance

43 in lecture hall
Slide 14 of 32: Countercurrent Architecture

Osmolar Gradient Generation in the Medulla

• Descending Limb: Impermeable to solutes, highly water permeable (AQP1)
• Ascending Limb: Active Na+/K+/2Cl- transport (NKCC2), water impermeable
• Medullary Interstitium reaches 1200 mOsm/kg at the hairpin turn
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Instructor Note: "Please answer the active comprehension poll on your right dock before we proceed to loop diuretic pharmacology."Mandatory Checkpoint
Active Lecture Poll38 votes cast

In the presence of high Antidiuretic Hormone (ADH / Vasopressin), where does the greatest volume of water reabsorption occur in the nephron?